Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salmeterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 19/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 2/20 | 0.98 |
| ▸ | TP53 | P04637 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | HPGD | P15428 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | THPO | P40225 | 1/20 | 0.98 |
| ▸ | MTOR | P42345 | 1/20 | 0.98 |
| ▸ | RAB9A | P51151 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 18/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salmeterol SCHEMBL29372524 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL29352164 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL2833182 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL19211132 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL9806070 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL18070 | 0.99 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL9545710 | 0.98 | ADRB2 (0.98) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| SCHEMBL19423025 | 0.90 | ADRB2 (0.83) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL4657562 | 0.89 | ADRB2 (0.81) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| SCHEMBL4637281 | 0.88 | ADRB2 (0.80) | ADRB2KDM4EMEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10303760-B2 | Cascading style sheet meta language performance | ENTIT SOFTWARE LLC (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170097927-A1 | CASCADING STYLE SHEET META LANGUAGE PERFORMANCE | MICRO FOCUS LLC (F/K/A ENTIT SOFTWARE LLC) | 2017-04-06 | — | — | US | disclosed |
| WO-2015160351-A1 | CASCADING STYLE SHEET META LANGUAGE PERFORMANCE | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2015-10-22 | — | — | WO | disclosed |