Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salmeterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 19/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 18/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salmeterol SCHEMBL29352164 | 1.00 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL29372524 | 1.00 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL2833182 | 1.00 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL19211132 | 1.00 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL9806070 | 1.00 | ADRB2 (1.00) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL17185987 | 0.99 | ADRB2 (0.98) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL9545710 | 0.99 | ADRB2 (0.98) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| SCHEMBL19423025 | 0.91 | ADRB2 (0.83) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| Salmeterol SCHEMBL4657562 | 0.90 | ADRB2 (0.81) | ADRB2KDM4EMEN1TP53CYP3A4 | |
| SCHEMBL4637281 | 0.89 | ADRB2 (0.80) | ADRB2KDM4EMEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 16085 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026099512-A1 | MEDICAMENT DISPENSER DEVICE | PORTAL MEDICAL LIMITED (GB) | 2026-05-15 | — | — | WO | claimed |
| US-20260021077-A1 | USE OF DEXPRAMIPEXOLE FOR THE TREATMENT OF MODERATE TO SEVERE ASTHMA | ARETEIA THERAPEUTICS, INC. (US) | 2026-01-22 | — | — | US | claimed |
| EP-4649960-A1 | USE OF LONG-ACTING ß2AR AGONIST IN PREPARATION OF DRUGS FOR TREATING CANCERS | Hong Kong Sxmeterol Pharmaceutical Co., Limited (HK) | 2025-11-19 | — | — | EP | claimed |
| EP-4642463-A1 | PHARMACEUTICAL COMPOSITIONS OF GREEN PROPELLANT | Cipla Limited (IN) | 2025-11-05 | — | — | EP | claimed |
| EP-4624054-A2 | METHODS FOR GENERATING AND DELIVERING DROPLETS TO THE PULMONARY SYSTEM USING A DROPLET DELIVERY DEVICE | Pneuma Respiratory, Inc. (US) | 2025-10-01 | — | — | EP | claimed |
| US-20250248938-A1 | MEDICAMENT DELIVERY FORMULATIONS, DEVICES AND METHODS | HONEYWELL INTERNATIONAL INC. (US) | 2025-08-07 | — | — | US | claimed |
| US-20250205206-A1 | USE OF DEXPRAMIPEXOLE FOR THE TREATMENT OF INADEQUATELY CONTROLLED MODERATE TO SEVERE ASTHMA | ARETEIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | US | claimed |
| WO-2025137230-A1 | USE OF DEXPRAMIPEXOLE FOR THE TREATMENT OF INADEQUATELY CONTROLLED MODERATE TO SEVERE ASTHMA | ARETEIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | claimed |
| US-12329727-B2 | Use of salmeterol as an anti-coronaviral agent | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2025-06-17 | — | — | US | claimed |
| CN-119970731-A | Inhalation dry powder preparation containing salmeterol and tiotropium salt composition and preparation method thereof | 南昌弘益科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| EP-0616523-A1 | MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 1994-09-28 | — | — | EP | claimed |
| CN-1078633-A | pharmaceutical preparation | GLAXO GROUP LTD (GB) | 1993-11-24 | — | — | CN | claimed |
| WO-1993015741-A1 | MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 1993-08-19 | — | — | WO | claimed |
| WO-1993011745-A1 | MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 1993-06-24 | — | — | WO | claimed |
| WO-1993011743-A1 | MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 1993-06-24 | — | — | WO | claimed |
| WO-1992005392-A1 | HEAT INSULATING COMPOSITE SYSTEM | GROCHAL PETER (DE) | 1992-04-02 | — | — | WO | claimed |
| US-4730106-A | Optical fiducial timing system for X-ray streak cameras with aluminum coated optical fiber ends | UNITED STATES DEPARTMENT OF ENERGY (US) | 1988-03-08 | — | — | US | claimed |
| US-4614399-A | Aerial drop wire splicer | AT&T TECHNOLOGIES, INC. (US) | 1986-09-30 | — | — | US | claimed |
| US-4572192-A | System for prevention of paroxysmal supraventricular tachycardia | BOARD OF REGENTS FOR THE UNIVERSITY OF OKLAHOMA (US) | 1986-02-25 | — | — | US | claimed |
| US-4006644-A | Apparatus for tensioning a safety belt | VOLKSWAGENWERK AKTIENGESELLSCHAFT (DT) | 1977-02-08 | — | — | US | claimed |