Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83759 | 0.83 | PPID (0.51) | SMN1; SMN2PPIDMAPTMEN1KMT2A | |
| SCHEMBL11080136 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2PPIDMAPTMEN1KMT2A | |
| SCHEMBL21582056 | 0.72 | SIGMAR1 (0.44) | SMN1; SMN2SIGMAR1MAPTPOLBMEN1 | |
| SCHEMBL21582057 | 0.72 | SIGMAR1 (0.44) | SMN1; SMN2SIGMAR1MAPTPOLBMEN1 | |
| SCHEMBL23715369 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2PPIDMAPTMEN1KMT2A | |
| SCHEMBL4849475 | 0.70 | PPID (0.52) | SMN1; SMN2PPIDSIGMAR1MAPTMEN1 | |
| SCHEMBL10965351 | 0.69 | SIGMAR1 (0.42) | SMN1; SMN2SIGMAR1MAPTPOLBMEN1 | |
| SCHEMBL11241912 | 0.69 | PPID (0.50) | SMN1; SMN2PPIDMAPTMEN1KMT2A | |
| SCHEMBL7851021 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2PPIDMAPTPOLBMEN1 | |
| SCHEMBL28079753 | 0.68 | ALDH1A1 (0.44) | SMN1; SMN2PPIDMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091926-B1 | SUBSTITUTED PYRAZOLE AND TRIAZOLE COMPOUNDS AS KSP INHIBITORS | NOVARTIS AG (CH) | 2015-10-21 | — | — | EP | disclosed |