Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 6/20 | 0.66 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18519816 | 0.80 | ALDH1A3 (1.00) | ALDH1A3ALDH3A1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29417647 | 0.80 | ALDH1A3 (1.00) | ALDH1A3ALDH3A1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11305457 | 0.78 | ALDH1A3 (0.96) | ALDH1A3ALDH3A1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5923918 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GRM1MAPTHPGD | |
| SCHEMBL30358126 | 0.77 | ALDH1A1 (0.67) | ALDH1A3ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL18155343 | 0.77 | ALDH1A1 (0.67) | ALDH1A3ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL4944339 | 0.75 | ALDH1A3 (0.73) | ALDH1A3ALDH3A1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15093728 | 0.75 | ALDH1A3 (1.00) | ALDH1A3ALDH3A1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17191282 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2GRM1MAPTHPGD | |
| SCHEMBL10975999 | 0.72 | MEN1 (0.57) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9468632-B2 | Methods and compositions for targeting cancer stem cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150297577-A1 | METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297577-A1 | METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | MCL1, CD44, TP53 | ALDH1A3 418/4885ALDH3A1 1027/4885ALDH1A1 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.