Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719450 | 0.88 | MAPT (0.77) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1718976 | 0.85 | THRB (0.77) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1719196 | 0.85 | MAPT (0.80) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1719394 | 0.84 | MAPT (0.78) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1719480 | 0.84 | MAPT (0.75) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1719159 | 0.83 | THRB (0.76) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1718868 | 0.83 | MAPT (0.77) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1719059 | 0.82 | MAPT (0.80) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1718398 | 0.82 | MAPT (0.75) | THRBRXFP1MAPTHPGDALDH1A1 | |
| SCHEMBL1718360 | 0.81 | MAPT (0.73) | THRBRXFP1MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |