Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.78 |
| ▸ | THRB | P10828 | 4/20 | 0.74 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | CASP1 | P29466 | 1/20 | 0.64 |
| ▸ | CASP7 | P55210 | 1/20 | 0.64 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719480 | 0.92 | MAPT (0.75) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1718868 | 0.91 | MAPT (0.77) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1719196 | 0.86 | MAPT (0.80) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1719450 | 0.86 | MAPT (0.77) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1719059 | 0.85 | MAPT (0.80) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL822505 | 0.85 | THRB (0.62) | MAPTTHRBRXFP1ALDH1A1HPGD | |
| SCHEMBL1718398 | 0.84 | MAPT (0.75) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1719283 | 0.84 | THRB (0.73) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1718360 | 0.84 | MAPT (0.73) | MAPTTHRBRXFP1POLBL3MBTL1 | |
| SCHEMBL1718976 | 0.83 | THRB (0.77) | MAPTTHRBRXFP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |