Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21089255 | 0.85 | CTSS (0.36) | LRRK2MAPK8MAPK9MAPK10L3MBTL1 | |
| SCHEMBL17177766 | 0.78 | LRRK2 (0.40) | LRRK2EPAS1KDM1APDE4B | |
| SCHEMBL17196425 | 0.78 | HRH4 (0.36) | MTORPIK3CA | |
| SCHEMBL18811836 | 0.76 | LRRK2 (0.35) | LRRK2MAPK8MAPK9MAPK10PDE4B | |
| SCHEMBL16511461 | 0.75 | ALDH1A1 (0.45) | LRRK2KMT2A | |
| SCHEMBL17173651 | 0.74 | LRRK2 (0.38) | LRRK2SLC22A12EPAS1PDE4B | |
| SCHEMBL12841775 | 0.74 | L3MBTL1 (0.41) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL12841673 | 0.74 | HTT (0.39) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL7215762 | 0.74 | L3MBTL1 (0.37) | LRRK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL29658828 | 0.74 | HTT (0.39) | MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015158427-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |