Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676290 | 0.88 | HTR2C (0.49) | KDM4ETDP1MEN1KMT2AMAPT | |
| SCHEMBL5073353 | 0.85 | HIF1A (0.55) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL9358281 | 0.79 | HIF1A (0.55) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL7326927 | 0.79 | CYP1A2 (0.45) | KDM4EALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL996544 | 0.78 | TDP1 (0.64) | KDM4EALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL9354501 | 0.78 | HPGD (0.52) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL22746859 | 0.78 | SSTR4 (0.56) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL27439189 | 0.77 | TRPM8 (0.55) | KDM4ETDP1MAPTSMN1; SMN2LIN28A | |
| SCHEMBL24192078 | 0.76 | PYCR1 (0.44) | PDK2TSHRNPSR1CYP1A2GBA1 | |
| SCHEMBL9555310 | 0.75 | ALDH1A1 (0.41) | KDM4EALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015159103-A1 | PIPERAZINE DERIVATIVES FOR TREATING DISORDERS | THE UNIVERSITY OF NOTTINGHAM (GB) | 2015-10-22 | — | — | WO | disclosed |