Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.41 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 7/20 | 0.40 |
| ▸ | P2RY2 | P41231 | 9/20 | 0.39 |
| ▸ | P2RY4 | P51582 | 5/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17198593 | 0.86 | SLC28A1 (0.41) | TDP1SLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL8771949 | 0.82 | POLB (0.50) | TDP1LMNASLC28A1SLC28A2SLC29A1 | |
| SCHEMBL6552632 | 0.82 | POLB (0.50) | TDP1LMNASLC28A1SLC28A2SLC29A1 | |
| SCHEMBL17198475 | 0.81 | LMNA (0.42) | LMNATHRBSMN1; SMN2HIF1AP2RY2 | |
| Uridine Triacetate SCHEMBL14950624 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A | |
| Uridine Triacetate SCHEMBL12900042 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A | |
| Uridine Triacetate SCHEMBL15279673 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A | |
| Uridine Triacetate SCHEMBL10350038 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A | |
| Uridine Triacetate SCHEMBL19308849 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A | |
| Uridine Triacetate SCHEMBL12928917 | 0.81 | LMNA (0.64) | TDP1LMNATHRBSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015161137-A1 | 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2015-10-22 | — | — | WO | disclosed |