Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536598 | 0.81 | LMNA (0.53) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10813233 | 0.81 | LMNA (0.53) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9068649 | 0.81 | LMNA (0.53) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2238447 | 0.81 | LMNA (0.53) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17198380 | 0.81 | TDP1 (0.45) | LMNATHRBP2RY2SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL7932700 | 0.80 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| Hydrochloric Acid SCHEMBL4977129 | 0.80 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10431963 | 0.80 | LMNA (0.50) | LMNATHRBMTORMDM2NCOA1 | |
| Hydrochloric Acid SCHEMBL4977138 | 0.80 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL11793030 | 0.79 | LMNA (0.57) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015161137-A1 | 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2015-10-22 | — | — | WO | disclosed |