Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10813233 | 1.00 | LMNA (0.53) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL9068649 | 1.00 | LMNA (0.53) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL6536598 | 1.00 | LMNA (0.53) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4977129 | 0.99 | LMNA (0.52) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4977138 | 0.99 | LMNA (0.52) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7932700 | 0.99 | LMNA (0.52) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL10431963 | 0.93 | LMNA (0.50) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL11793030 | 0.92 | LMNA (0.57) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL11807658 | 0.91 | LMNA (0.48) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL10589686 | 0.91 | LMNA (0.48) | LMNATHRBSMN1; SMN2HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528930-B1 | 4'-AZIDO-NUCLEOSIDES AS ANTI-HCV COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2013-10-30 | — | — | EP | disclosed |
| EP-2528930-A1 | 4 ' - AZIDO - NUCLEOSIDES AS ANTI - HCV COMPUNDS | F. Hoffmann-La Roche AG (CH) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092158-A1 | 4 ' - AZIDO - NUCLEOSIDES AS ANTI - HCV COMPUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-04 | — | — | WO | disclosed |
| EP-1565481-B1 | ANTIVIRAL NUCLEOSIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | EP | disclosed |
| EP-1565481-A1 | ANTIVIRAL NUCLEOSIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-24 | — | — | EP | disclosed |
| US-6846810-B2 | Hepatitits virus | ROCHE PALO ALTO LLC (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040121980-A1 | Antiviral nucleoside derivatives | ROCHE PALO ALTO LLC | 2004-06-24 | — | — | US | disclosed |
| WO-2004046159-A1 | ANTIVIRAL NUCLEOSIDE DERIVATIVES | F. HOFFMANN-LA-ROCHE AG (CH) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121980-A1 | Antiviral nucleoside derivatives | SLC29A1, SAMHD1, NUDT1 | LMNA 1974/4885THRB 4178/4885SMN1; SMN2 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.