Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL1675406 | 1.00 | BLM (0.50) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL3105895 | 1.00 | BLM (0.50) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL7707543 | 0.95 | BLM (0.56) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL727085 | 0.95 | BLM (0.56) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL28174334 | 0.95 | BLM (0.56) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL5789307 | 0.95 | BLM (0.56) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL1275425 | 0.95 | BLM (0.56) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL18954801 | 0.92 | ALOX15 (0.42) | BLMKMT2AALOX15PMP22GRM8 | |
| Glutamine SCHEMBL18954804 | 0.92 | ALOX15 (0.42) | BLMKMT2AALOX15PMP22GRM8 | |
| Proline SCHEMBL1675405 | 0.92 | ALOX15 (0.41) | BLMKMT2AALOX15PMP22NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937096-B1 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | UNIV WUERZBURG J MAXIMILIANS (DE) | 2019-08-21 | — | — | EP | claimed |
| US-10105414-B2 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2018-10-23 | — | — | US | claimed |
| US-20170042969-A1 | PEPTIDES DERIVED FROM RS1 WHICH DOWN-REGULATE GLUCOSE ABSORPTION AFTER A GLUCOSE RICH MEAL AND INCREASE INSULIN SENSITIVITY | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2017-02-16 | — | — | US | claimed |
| EP-2937096-A1 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | Julius-Maximilians-Universität Würzburg (DE) | 2015-10-28 | — | — | EP | claimed |
| EP-2937096-B1 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | UNIV WUERZBURG J MAXIMILIANS (DE) | 2019-08-21 | — | — | EP | disclosed |
| US-10105414-B2 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2018-10-23 | — | — | US | disclosed |
| US-20170042969-A1 | PEPTIDES DERIVED FROM RS1 WHICH DOWN-REGULATE GLUCOSE ABSORPTION AFTER A GLUCOSE RICH MEAL AND INCREASE INSULIN SENSITIVITY | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2017-02-16 | — | — | US | disclosed |
| WO-2015162214-A1 | PEPTIDES DERIVED FROM RS1 WHICH DOWN-REGULATE GLUCOSE ABSORPTION AFTER A GLUCOSE RICH MEAL AND INCREASE INSULIN SENSITIVITY | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2015-10-29 | — | — | WO | disclosed |
| EP-2937096-A1 | Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity | Julius-Maximilians-Universität Würzburg (DE) | 2015-10-28 | — | — | EP | disclosed |