Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | QARS1 | P47897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL1675406 | 0.92 | BLM (0.50) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL17199762 | 0.92 | BLM (0.50) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL3105895 | 0.92 | BLM (0.50) | ALOX15BLMPMP22KMT2ANOS2 | |
| Serine SCHEMBL17199761 | 0.91 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2ANOS2 | |
| Proline SCHEMBL3105891 | 0.88 | KMT2A (0.38) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL1275425 | 0.86 | BLM (0.56) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL28174334 | 0.86 | BLM (0.56) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL5789307 | 0.86 | BLM (0.56) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL7707543 | 0.86 | BLM (0.56) | ALOX15BLMPMP22KMT2ANOS2 | |
| Glutamine SCHEMBL727085 | 0.86 | BLM (0.56) | ALOX15BLMPMP22KMT2ANOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006170-B2 | Compositions for elastogenesis and connective tissue treatment | HUMAN MATRIX SCIENCES, LLC (US) | 2015-04-14 | — | — | US | disclosed |
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110081322-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2011-04-07 | — | — | US | disclosed |