Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 13/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MGLL | Q99685 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3644401 | 0.87 | KDM4E (0.79) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL3590486 | 0.87 | FAAH (1.00) | FAAH | |
| SCHEMBL3355088 | 0.84 | FAAH (0.74) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL16673798 | 0.82 | FAAH (0.74) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL1759013 | 0.81 | FAAH (0.66) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL3642080 | 0.81 | FAAH (0.75) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL7646963 | 0.80 | KDM4E (0.75) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL2931334 | 0.80 | SIGMAR1 (0.74) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL5471849 | 0.78 | FAAH (0.71) | FAAHLMNAKDM4EALDH1A1GAA | |
| SCHEMBL16673541 | 0.78 | FAAH (0.76) | FAAHLMNAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937341-A1 | 4-(BENZYL)-PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS | Janssen Pharmaceutica N.V. (BE) | 2015-10-28 | — | — | EP | disclosed |