Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720115 | 0.85 | CYP11B2 (0.45) | HRH4PARP1RAB9A | |
| SCHEMBL655293 | 0.82 | CYP11B2 (0.46) | HRH4PARP1HRH3RAB9A | |
| SCHEMBL655824 | 0.79 | HRH4 (0.46) | HRH4HRH3RAB9A | |
| SCHEMBL654247 | 0.78 | HRH4 (0.48) | HRH4HRH3HDAC1HDAC2HDAC3 | |
| SCHEMBL654788 | 0.77 | HRH4 (0.51) | HRH4PARP1HRH3LMNAHTT | |
| SCHEMBL654678 | 0.74 | HRH4 (0.47) | HRH4PARP1HRH3CHEK2 | |
| SCHEMBL653903 | 0.73 | HSP90AA1 (0.51) | HRH4ABL1BCR | |
| SCHEMBL651846 | 0.73 | HRH4 (0.64) | HRH4PARP1HRH3 | |
| SCHEMBL652590 | 0.73 | HRH4 (0.47) | HRH4PARP1HRH3CHEK2 | |
| SCHEMBL654404 | 0.72 | HRH4 (0.59) | HRH4PARP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |