Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655293 | 0.97 | CYP11B2 (0.46) | CYP11B2HRH4GRIN2BGSK3BALDH1A1 | |
| SCHEMBL655824 | 0.95 | HRH4 (0.46) | CYP11B2HRH4GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL1720114 | 0.85 | HRH4 (0.42) | HRH4PARP1RAB9A | |
| SCHEMBL656567 | 0.78 | PI4KB (0.46) | CYP11B2GRIN2BALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL654247 | 0.78 | HRH4 (0.48) | HRH4SMN1; SMN2MAPTGFER | |
| SCHEMBL654788 | 0.77 | HRH4 (0.51) | HRH4ALDH1A1MAPTPARP1MAPK1 | |
| SCHEMBL655881 | 0.77 | ALDH1A1 (0.45) | HRH4ALDH1A1SMN1; SMN2TSHRMAPT | |
| SCHEMBL653407 | 0.77 | HRH4 (0.52) | HRH4ALDH1A1TSHRMAPTPARP1 | |
| SCHEMBL654044 | 0.77 | GFER (0.53) | HRH4ALDH1A1MAPTPARP1TDP1 | |
| SCHEMBL654230 | 0.76 | HRH4 (0.44) | CYP11B2HRH4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |