Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056388 | 0.86 | MAPT (0.59) | SMN1; SMN2ALDH1A1RAB9AMAPTMAPK1 | |
| SCHEMBL8202631 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1RAB9AMAPTMAPK1 | |
| SCHEMBL17202971 | 0.85 | ATM (0.56) | SMN1; SMN2ALDH1A1RAB9AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL17202790 | 0.84 | ATM (0.55) | SMN1; SMN2ALDH1A1RAB9AMAPTLMNA | |
| SCHEMBL4441360 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL8489898 | 0.81 | ATM (0.77) | SMN1; SMN2ALDH1A1RAB9ALMNAATM | |
| SCHEMBL2054582 | 0.81 | MAPT (0.55) | SMN1; SMN2ALDH1A1RAB9AMAPTMAPK1 | |
| SCHEMBL17206298 | 0.80 | ATM (0.58) | SMN1; SMN2ALDH1A1RAB9AMAPTMAPK1 | |
| SCHEMBL13657275 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9AMAPTMAPK1TSHR | |
| SCHEMBL10174568 | 0.80 | ATM (0.75) | SMN1; SMN2ALDH1A1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134408-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10093683-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-3134408-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-03-01 | — | — | EP | disclosed |
| US-20170044183-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015164308-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044183-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | SMN1; SMN2 4591/4885ALDH1A1 3635/4885RAB9A 1961/4885 |
| US-10093683-B2 | Factor XIa inhibitors | F11, F12, SERPINC1 | SMN1; SMN2 4445/4885ALDH1A1 3478/4885RAB9A 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.