Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202799 | 0.87 | EPHX2 (0.48) | ATMMAPTMAPK1RAB9AALDH1A1 | |
| Lithium Ion SCHEMBL18490923 | 0.86 | EPHX2 (0.47) | ATMMAPTALDH1A1 | |
| SCHEMBL32660726 | 0.85 | ALDH1A1 (0.70) | ATMMAPTNPSR1MAPK1RAB9A | |
| SCHEMBL14467294 | 0.81 | ALDH1A1 (0.66) | ATMMAPTNPSR1MAPK1RAB9A | |
| SCHEMBL17203124 | 0.80 | SMN1; SMN2 (0.67) | ATMMAPTNPSR1MAPK1RAB9A | |
| SCHEMBL24317392 | 0.79 | MAPK1 (0.57) | ATMMAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL26814997 | 0.78 | ALDH1A1 (0.56) | ATMMAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL273218 | 0.78 | PDK1 (0.60) | MAPTNPSR1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27444507 | 0.77 | MAPT (0.73) | ATMMAPTNPSR1MAPK1RAB9A | |
| SCHEMBL1742370 | 0.76 | SMN1; SMN2 (0.60) | ATMMAPTNPSR1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134408-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10093683-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-3134408-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-03-01 | — | — | EP | disclosed |
| US-20170044183-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015164308-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044183-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | ATM 1476/4885MAPT 3611/4885NPSR1 3358/4885 |
| US-10093683-B2 | Factor XIa inhibitors | F11, F12, SERPINC1 | ATM 1457/4885MAPT 3721/4885NPSR1 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.