Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.62 |
| ▸ | FOS | P01100 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 3/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203192 | 0.77 | TRPV1 (1.00) | TRPV1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15259679 | 0.71 | FOS (0.54) | TRPV1FOSTTRJUNNR3C1 | |
| SCHEMBL27718977 | 0.70 | FOS (0.59) | TRPV1FOSTTRJUNNR3C1 | |
| SCHEMBL17202848 | 0.70 | TRPV1 (0.55) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL29370506 | 0.69 | HTR1A (0.59) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL29549298 | 0.69 | HTR1A (0.59) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL6409253 | 0.69 | CYP3A4 (0.54) | TRPV1FOSTTRJUNNR3C1 | |
| SCHEMBL1286871 | 0.69 | HTR1A (0.59) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL299310 | 0.69 | HTR1A (0.59) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL28162513 | 0.69 | HTR1A (0.59) | TRPV1CYP2A6CYP2E1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |