Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203305 | 0.90 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17205617 | 0.82 | TRPV1 (1.00) | TRPV1CYP2D6CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL17205697 | 0.80 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17205509 | 0.77 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17203182 | 0.77 | TRPV1 (0.62) | TRPV1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14644393 | 0.76 | TRPV1 (0.70) | TRPV1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5348698 | 0.74 | CYP1A2 (0.90) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3266072 | 0.72 | HPGD (0.90) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14034814 | 0.72 | TRPV1 (0.93) | TRPV1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17205531 | 0.72 | TRPV1 (1.00) | TRPV1CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | claimed |
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |