Lactic Acid

Lactic Acid

SCHEMBL1720338

CC(O)C(=O)O.NC(N)COc1cccc2nc3ccccc3cc12

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1

The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 known ✓ Q99720 4/20 0.40
HTR2A known ✓ P28223 3/20 0.40
DRD3 known ✓ P35462 1/20 0.40
TLR8 Q9NR97 2/20 0.45
NR2E1 Q9Y466 5/20 0.41
ALDH1A1 P00352 5/20 0.40
LMNA P02545 3/20 0.40
KDM4E B2RXH2 3/20 0.40
KMT2A Q03164 3/20 0.40
HPGD P15428 2/20 0.40
NPC1 O15118 1/20 0.40
GLA P06280 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
PTBP1 P26599 1/20 0.40
RAB9A P51151 1/20 0.40
RCE1 Q9Y256 1/20 0.40
CYP2D6 P10635 4/20 0.40
ADRB2 P07550 4/20 0.40
ADRB1 P08588 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lactic Acid SCHEMBL11334625 0.99 TLR8 (0.44) TLR8NR2E1ALDH1A1LMNAKDM4E
SCHEMBL10777924 0.89 ALDH1A1 (0.50) TLR8NR2E1ALDH1A1LMNAKDM4E
Lactic Acid SCHEMBL1720336 0.80 KDM4E (0.43) TLR8ALDH1A1LMNAKDM4EKMT2A
SCHEMBL10886126 0.78 TLR8 (0.38) TLR8NR2E1ALDH1A1LMNAKDM4E
Hydrochloric Acid SCHEMBL10885463 0.77 TLR8 (0.37) TLR8ALDH1A1LMNAKDM4EKMT2A
SCHEMBL10926264 0.77 MAPT (0.43) TLR8ALDH1A1LMNAKDM4EKMT2A
Acridine SCHEMBL10926258 0.76 ALDH1A1 (0.58) TLR8ALDH1A1LMNAKDM4EKMT2A
Lactic Acid SCHEMBL5515418 0.76 ALDH1A1 (0.44) TLR8ALDH1A1LMNAKDM4EKMT2A
Hydrochloric Acid SCHEMBL11373808 0.76 TLR8 (0.50) TLR8NR2E1ALDH1A1LMNAKDM4E
Lactic Acid SCHEMBL28885529 0.75 ALDH1A1 (0.43) TLR8ALDH1A1LMNAKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4065445-A Pregnancy-specific β1 -glycoprotein and process for isolating it BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1977-12-27 US claimed
US-4041021-A MULTISTAGE PRECIPITATION, DISPERSION, SEPARATION AND ELECTROPHORESIS BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1977-08-09 US claimed
US-3930953-A GLUCOSE OXIDASE POOR IN CATALASE AND PROCESS FOR OBTAINING IT BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1976-01-06 US claimed
US-3931399-A MULTISTAGE FROM EXTRACTION OF HUMAN PLACENTAE BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1976-01-06 US claimed
EP-1817339-B1 PURIFICATION OF RECOMBINANT HUMAN FACTOR XIII ZYMOGENETICS INC (US) 2012-01-11 EP disclosed
EP-0603215-B1 PURIFICATION OF FACTOR XIII ZYMOGENETICS INC (US) 1997-10-29 EP disclosed
US-5612456-A PURIFYING FACTOR XIII FROM A BIOLOGICAL FLUID ZYMOGENETICS, INC. (US) 1997-03-18 US disclosed
EP-0603215-A1 PURIFICATION OF FACTOR XIII. ZYMOGENETICS INC (US) 1994-06-29 EP disclosed
US-5204447-A Precipitating by adjustment of pH to 5.5 to 6.5, recovering ZYMOGENETICS, INC. (US) 1993-04-20 US disclosed
WO-1993003147-A1 PURIFICATION OF FACTOR XIII ZYMOGENETICS, INC. (US) 1993-02-18 WO disclosed
EP-0442964-A1 PURIFICATION OF FACTOR XIII ZYMOGENETICS, INC. (US) 1991-08-28 EP disclosed
WO-1990005777-A1 PURIFICATION OF FACTOR XIII ZYMOGENETICS, INC. (US) 1990-05-31 WO disclosed
US-4191533-A Pregnancy-specific β1 -glycoprotein and process for isolating it BEHRINGWERKE AKTIENGESELLSCHAFT (DE) 1980-03-04 US disclosed
US-4065445-A Pregnancy-specific β1 -glycoprotein and process for isolating it BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1977-12-27 US disclosed
US-4041021-A MULTISTAGE PRECIPITATION, DISPERSION, SEPARATION AND ELECTROPHORESIS BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed
US-4018885-A Steroid-binding globulin and process for preparing it and antibodies thereto BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1977-04-19 US disclosed
US-3930953-A GLUCOSE OXIDASE POOR IN CATALASE AND PROCESS FOR OBTAINING IT BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed
US-3931399-A MULTISTAGE FROM EXTRACTION OF HUMAN PLACENTAE BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed
US-3931399-A MULTISTAGE FROM EXTRACTION OF HUMAN PLACENTAE BEHRINGWERKE AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed
US-3904751-A Process for isolating a fibrin stabilizing factor from human placenta BEHRINGWERKE AG 1975-09-09 US disclosed