Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.49 |
| ▸ | TMIGD3 | P0DMS9 | 5/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720857 | 0.71 | ALDH1A1 (0.45) | ADORA2AADORA2BADORA1TMIGD3ADORA3 | |
| SCHEMBL21396441 | 0.70 | ADORA2A (0.60) | ADORA2AADORA2BADORA1TMIGD3ADORA3 | |
| SCHEMBL7146850 | 0.68 | XDH (0.59) | ADORA2AADORA2BADORA1ALDH1A1KDM4E | |
| SCHEMBL2686441 | 0.68 | ADORA2B (0.52) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL1725022 | 0.67 | ADORA2B (0.46) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL12958953 | 0.66 | PNP (0.46) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL27710751 | 0.65 | ADORA2A (0.52) | ADORA2AADORA2BALDH1A1GAAPDE4B | |
| SCHEMBL8872400 | 0.64 | ADORA2B (0.69) | ADORA2AADORA2BADORA1ALDH1A1KDM4E | |
| SCHEMBL23393089 | 0.64 | SMN1; SMN2 (0.46) | ADORA2AADORA2BADORA1ADORA3KDM4E | |
| SCHEMBL1720432 | 0.64 | ADORA2A (0.51) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | claimed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | claimed |