Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095078 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1NR1H2NR1H3MAPT | |
| SCHEMBL1061985 | 0.78 | KDM4E (0.72) | KDM4EALDH1A1NR1H2NR1H3MAPT | |
| SCHEMBL17204366 | 0.77 | ALOX5 (0.58) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17204571 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1NR1H2NR1H3KMT2A | |
| SCHEMBL1061682 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1NR1H2NR1H3MAPT | |
| SCHEMBL1062838 | 0.72 | KDM4E (1.00) | KDM4EALDH1A1NR1H2NR1H3MAPT | |
| SCHEMBL7901087 | 0.71 | CYP3A4 (0.58) | KDM4ENR1H2NR1H3MEN1MAPT | |
| SCHEMBL20095236 | 0.68 | PDE3B (0.55) | KDM4EALDH1A1MAPTALOX5LMNA | |
| SCHEMBL46291 | 0.68 | PDE5A (0.50) | ALDH1A1MEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL4511837 | 0.68 | PDE5A (0.50) | KDM4EALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620870-B | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2023-01-03 | — | — | CN | disclosed |
| CN-111620870-A | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-106414445-B | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2020-07-03 | — | — | CN | disclosed |
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | Universitéde Montréal (CA) | 2020-05-12 | — | — | US | disclosed |
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | Universitéde Montréal (CA) | 2020-05-12 | — | — | US | disclosed |
| EP-3134409-B1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIV MONTREAL (CA) | 2020-02-12 | — | — | EP | disclosed |
| EP-3134409-B1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIV MONTREAL (CA) | 2020-02-12 | — | — | EP | disclosed |
| EP-3134409-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2017-03-01 | — | — | EP | disclosed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | disclosed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | disclosed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | disclosed |
| WO-2015161373-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015161373-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | HPGDS, HCLS1, THPO | KDM4E 1764/4885ALDH1A1 19/4885NR1H2 1993/4885 |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | HPGDS, HCLS1, THPO | KDM4E 1764/4885ALDH1A1 19/4885NR1H2 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.