Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 5/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38373 | 0.86 | PDE5A (0.61) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL37981 | 0.86 | PDE5A (0.66) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL10084040 | 0.84 | PDE5A (0.59) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL4511837 | 0.83 | PDE5A (0.50) | PDE5ACDC7DBF4PNPTSHR | |
| SCHEMBL46453 | 0.82 | KDM4E (0.50) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL38484 | 0.82 | PDE5A (0.57) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL10083509 | 0.82 | PDE5A (0.58) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL46289 | 0.82 | PDE5A (0.76) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL46296 | 0.80 | PDE5A (0.56) | PDE5ACDC7DBF4CCNE1CDK2 | |
| SCHEMBL3494152 | 0.76 | KMT2A (0.63) | LMNAL3MBTL1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |