Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713040 | 0.83 | PTGIR (0.51) | MEN1KMT2ATSHRTRPM8NPSR1 | |
| SCHEMBL9140139 | 0.78 | ALDH1A1 (0.42) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL7244019 | 0.75 | TSHR (0.44) | KDM4EMEN1KMT2ATSHRTRPM8 | |
| SCHEMBL4601280 | 0.74 | PAX8 (0.50) | KMT2ATSHRNPSR1MAPTPTGIR | |
| SCHEMBL16776764 | 0.74 | MAPK14 (0.43) | KDM4ERECQLMEN1KMT2ATSHR | |
| SCHEMBL9952361 | 0.73 | KDM4E (0.55) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL7623811 | 0.73 | AR (0.44) | MEN1KMT2ATSHRPTGIR | |
| SCHEMBL14163844 | 0.72 | ALDH1A1 (0.41) | KDM4EMEN1KMT2ATSHRHPGD | |
| SCHEMBL31393778 | 0.72 | PAX8 (0.56) | APAF1MEN1KMT2ATSHRTRPM8 | |
| SCHEMBL14570732 | 0.72 | TSHR (0.39) | KDM4EAPAF1RECQLCASP6CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170306386-A1 | YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE | THE UNIVERSITY OF CHICAGO (US) | 2017-10-26 | — | — | US | disclosed |
| US-20130005608-A1 | YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE | THE UNIVERSITY OF CHICAGO (US) | 2013-01-03 | — | — | US | disclosed |
| EP-1392849-B2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIV CHICAGO (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-2319936-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-1392849-B1 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIV CHICAGO (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1793001-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1392849-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | THE UNIVERSITY OF CHICAGO (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002065136-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIVERSITY OF CHICAGO (US) | 2002-08-22 | — | — | WO | disclosed |