Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17205350 | 1.00 | TRPA1 (0.44) | TRPA1RXFP1L3MBTL1DYRK1AATM | |
| SCHEMBL17204949 | 0.97 | TRPA1 (0.42) | TRPA1RXFP1L3MBTL1DYRK1AATM | |
| SCHEMBL17205371 | 0.85 | TRPA1 (0.51) | TRPA1RXFP1L3MBTL1DYRK1AMAP3K12 | |
| SCHEMBL17210373 | 0.82 | ALDH1A1 (0.42) | TRPA1RXFP1L3MBTL1ATMCYP1A2 | |
| SCHEMBL18539062 | 0.81 | TRPA1 (0.43) | TRPA1RXFP1L3MBTL1ATMCYP1A2 | |
| SCHEMBL17210408 | 0.81 | TRPA1 (0.43) | TRPA1RXFP1L3MBTL1ATMCYP1A2 | |
| SCHEMBL18539052 | 0.78 | TRPA1 (0.59) | TRPA1RXFP1CYP1A2 | |
| SCHEMBL17205457 | 0.78 | TRPA1 (0.59) | TRPA1RXFP1CYP1A2 | |
| SCHEMBL17205223 | 0.78 | DYRK1A (0.40) | TRPA1RXFP1L3MBTL1DYRK1AATM | |
| SCHEMBL17205449 | 0.77 | TRPA1 (0.48) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134410-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | Hydra Biosciences, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015164643-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2015-10-29 | — | — | WO | disclosed |