SCHEMBL17205186

SCHEMBL17205186

Cc1cc2nc(N)oc2c2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 3/20 0.54
BACE1 P56817 1/20 0.47
ELANE P08246 1/20 0.46
TYMS P04818 1/20 0.44
CYP1A2 P05177 5/20 0.42
NCF1 P14598 1/20 0.40
ALDH1A1 P00352 4/20 0.39
NQO2 P16083 1/20 0.38
KMT2A Q03164 2/20 0.38
CYP1B1 Q16678 1/20 0.38
KDM4E B2RXH2 3/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPFFR1 Q9GZQ6 1/20 0.37
NPFFR2 Q9Y5X5 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
RAB9A P51151 3/20 0.37
HPGD P15428 3/20 0.37
HSD17B10 Q99714 2/20 0.37
NPC1 O15118 2/20 0.37
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29683232 1.00 NUDT1 (0.54) NUDT1BACE1ELANETYMSCYP1A2
SCHEMBL18548985 0.82 ELANE (0.49) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL31694921 0.82 ELANE (0.49) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL31694957 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL18548984 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL18548997 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL18549020 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL31694955 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL31694934 0.79 ELANE (0.46) NUDT1BACE1ELANECYP1A2NCF1
SCHEMBL18548994 0.79 ELANE (0.46) NUDT1ELANECYP1A2ALDH1A1NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12629356-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof IOVANCE BIOTHERAPEUTICS, INC. (US) 2026-05-19 US claimed
EP-3565586-B1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF IOVANCE BIOTHERAPEUTICS INC (US) 2025-10-08 EP claimed
US-20230210966-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF LION BIOTECHNOLOGIES, INC. 2023-07-06 US claimed
US-11357841-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof IOVANCE BIOTHERAPEUTICS, INC. (US) 2022-06-14 US claimed
US-11173146-B2 Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-11-16 US claimed
EP-3565586-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF Iovance Biotherapeutics, Inc. (US) 2019-11-13 EP claimed
WO-2018129336-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF IOVANCE BIOTHERAPEUTICS, INC. (US) 2018-07-12 WO claimed
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS WRIGHT STATE UNIVERSITY (US) 2017-10-19 US claimed
US-20170056376-A1 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE UNIV CALIFORNIA (US) 2017-03-02 US claimed
US-12629356-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof IOVANCE BIOTHERAPEUTICS, INC. (US) 2026-05-19 US disclosed
EP-3565586-B1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF IOVANCE BIOTHERAPEUTICS INC (US) 2025-10-08 EP disclosed
US-20230210966-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF LION BIOTECHNOLOGIES, INC. 2023-07-06 US disclosed
US-20230210966-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF LION BIOTECHNOLOGIES, INC. 2023-07-06 US disclosed
US-11357841-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof IOVANCE BIOTHERAPEUTICS, INC. (US) 2022-06-14 US disclosed
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS WRIGHT STATE UNIVERSITY (US) 2017-10-19 US disclosed
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS WRIGHT STATE UNIVERSITY (US) 2017-10-19 US disclosed
US-20170056376-A1 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE UNIV CALIFORNIA (US) 2017-03-02 US disclosed
US-20170056376-A1 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE UNIV CALIFORNIA (US) 2017-03-02 US disclosed
US-20170056376-A1 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE UNIV CALIFORNIA (US) 2017-03-02 US disclosed
WO-2015164816-A2 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+-ACTIVATED K+ CHANNEL KCA3.1 AND THEIR METHODS OF USE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-10-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11173146-B2 Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use KCNN3, KCNN1, KCNN2 NUDT1 2147/4885BACE1 4033/4885ELANE 2595/4885
US-20230210966-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF KCNN3, KCNK3, KCNA3 NUDT1 2617/4885BACE1 4654/4885ELANE 2747/4885
US-12629356-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof PBK, IL2, KCNN3 NUDT1 2879/4885BACE1 3173/4885ELANE 4828/4885
US-11357841-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof KCNN3, KCNK3, KCNA3 NUDT1 2617/4885BACE1 4654/4885ELANE 2747/4885
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS KCNN3, KCNN2, KCNN1 NUDT1 3270/4885BACE1 718/4885ELANE 2328/4885
US-20170056376-A1 SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE KCNN3, KCNN1, KCNN2 NUDT1 2147/4885BACE1 4033/4885ELANE 2595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.