Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831727 | 0.78 | TDP1 (0.47) | EPHX1SMN1; SMN2TDP1ALDH1A1TSHR | |
| SCHEMBL6433689 | 0.77 | TDP1 (0.38) | EPHX1TDP1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL967503 | 0.76 | TDP1 (0.53) | EPHX1TDP1ALDH1A1TSHRKMT2A | |
| Ammonia Solution, Strong SCHEMBL3290266 | 0.74 | TDP1 (0.52) | EPHX1TDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL27996450 | 0.74 | TDP1 (0.52) | EPHX1TDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL11066352 | 0.73 | — | — | |
| SCHEMBL8404812 | 0.73 | EPHX1 (0.38) | EPHX1SMN1; SMN2TDP1ALDH1A1TSHR | |
| Hydroxyamine SCHEMBL10630230 | 0.73 | TDP1 (0.50) | EPHX1TDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL9257529 | 0.72 | CTSK (0.45) | TDP1ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL975107 | 0.71 | TSHR (0.38) | TDP1ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134402-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015162075-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-29 | — | — | WO | disclosed |