SCHEMBL9257529

SCHEMBL9257529

CCC(NC(=O)OOC(C)(C)C)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSK P43235 6/20 0.45
CTSS P25774 5/20 0.45
POLB P06746 1/20 0.36
PPARA Q07869 6/20 0.35
PPARG P37231 5/20 0.35
ACE P12821 1/20 0.35
PPARD Q03181 2/20 0.34
CTSL P07711 1/20 0.34
CTSB P07858 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HTT P42858 1/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29683039 0.83 CTSK (0.50) CTSKCTSSMME
SCHEMBL835996 0.81 CTSK (0.64) CTSKCTSSPPARAPPARGACE
SCHEMBL318796 0.81 CTSK (0.64) CTSKCTSSPPARAPPARGACE
SCHEMBL1951491 0.81 CTSK (0.64) CTSKCTSSPPARAPPARGACE
SCHEMBL6497912 0.81 CTSK (0.35) CTSKCTSSPPARAPPARGACE
SCHEMBL193660 0.77 TGFBR1 (0.44) CTSKCTSSPOLBMEN1KMT2A
SCHEMBL193659 0.77 TGFBR1 (0.44) CTSKCTSSPOLBMEN1KMT2A
SCHEMBL18506232 0.77 TGFBR1 (0.44) CTSKCTSSPOLBMEN1KMT2A
SCHEMBL9830204 0.73 ATM (0.40) CTSKCTSSPOLBCYP1A2CYP2C9
SCHEMBL17206239 0.72 EPHX1 (0.38) CTSKCTSSPOLBMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0650368-A1 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1995-05-03 EP disclosed
WO-1994000095-A2 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1994-01-06 WO disclosed