Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208695 | 0.93 | RAD52 (0.62) | RAD52MAPTKMT2AATMNPSR1 | |
| SCHEMBL17208640 | 0.93 | ABL1 (0.56) | RAD52MAPTKMT2AATMNPSR1 | |
| SCHEMBL17208621 | 0.80 | DDR1 (0.68) | MAPTKMT2AATMNPSR1EGFR | |
| SCHEMBL17208648 | 0.79 | EGFR (0.59) | MAPTKMT2AATMNPSR1KDM4E | |
| SCHEMBL17208696 | 0.78 | RAD52 (0.80) | RAD52ATM | |
| SCHEMBL30466487 | 0.76 | KIT (0.70) | MAPTKMT2ANPSR1FGFR1KDR | |
| SCHEMBL17208643 | 0.76 | RAD52 (0.67) | RAD52EGFRBRAF | |
| SCHEMBL17208617 | 0.75 | EGFR (0.60) | RAD52MAPTKMT2AATMNPSR1 | |
| SCHEMBL28516136 | 0.72 | ABL1 (0.87) | FGFR1KIT | |
| SCHEMBL17208720 | 0.72 | RAD52 (0.95) | RAD52ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |