Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720878 | 1.00 | CYP11B2 (0.50) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL1720877 | 1.00 | CYP11B2 (0.50) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL1721775 | 1.00 | CYP11B2 (0.50) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL1721426 | 1.00 | CYP11B2 (0.50) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL3091992 | 0.92 | OPRM1 (0.48) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL3091989 | 0.92 | OPRM1 (0.48) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL13153724 | 0.84 | TNKS (0.52) | CYP11B2ALDH1A1OPRM1OPRL1NAMPT | |
| SCHEMBL13833169 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAAHTTCYP3A4LMNA | |
| SCHEMBL13833170 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAAHTTCYP3A4LMNA | |
| SCHEMBL1723397 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAAHTTCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406266-B1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN SEIYAKU KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| EP-2406266-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| US-8071591-B2 | 7-cycloalkylaminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-06 | — | — | US | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceuticals Co. Ltd | 2010-09-16 | — | — | US | disclosed |
| WO-2010104205-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010104205-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234367-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | GSK3B, GSK3A, GSKIP | CYP11B2 341/4885ALDH1A1 3225/4885OPRM1 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.