Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342304 | 1.00 | MC4R (0.39) | MC4RHSD11B1CTSDMAPK1EPHX2 | |
| SCHEMBL458294 | 0.83 | CA12 (0.39) | EPHX2SSTR4KMT2A | |
| SCHEMBL3475585 | 0.71 | ADRB2 (0.36) | HSD11B1MAPK1EPHX2MAOAMAOB | |
| SCHEMBL1721157 | 0.71 | SSTR4 (0.36) | MC4REPHX2SSTR4 | |
| SCHEMBL21359176 | 0.70 | SLC6A4 (0.42) | HSD11B1MAPK1MAOAMAOBCYP2D6 | |
| SCHEMBL13735783 | 0.70 | ALDH1A1 (0.39) | MC4RCYP2D6CYP1A2CYP2C19KDM4E | |
| SCHEMBL16653710 | 0.70 | ALDH1A1 (0.39) | MC4RCYP2D6CYP1A2CYP2C19KDM4E | |
| SCHEMBL15880135 | 0.70 | ALDH1A1 (0.39) | MC4RCYP2D6CYP1A2CYP2C19KDM4E | |
| SCHEMBL21359111 | 0.69 | ALDH1A1 (0.36) | HSD11B1MAPK1EPHX2MAOAMAOB | |
| SCHEMBL2225974 | 0.66 | KDM1A (0.42) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406256-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103335-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |