Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18493700 | 0.78 | PTPN1 (0.45) | PTPN1HTR2CGHSRKDM4EUSP2 | |
| SCHEMBL20266985 | 0.77 | PTPN1 (0.52) | PTPN1KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL20267071 | 0.76 | PTPN1 (0.51) | PTPN1KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL22307347 | 0.73 | PTPN1 (0.54) | PTPN1GHSRSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL7185412 | 0.72 | PTPN1 (0.50) | PTPN1GHSRSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL20287868 | 0.72 | BCHE (0.47) | PTPN1MEN1KMT2A | |
| SCHEMBL22040413 | 0.69 | PTPN1 (0.47) | PTPN1SMN1; SMN2KDM4EUSP2HPGD | |
| SCHEMBL19403963 | 0.69 | F2 (0.41) | PTPN1GHSRKDM4EHPGDHSD17B10 | |
| SCHEMBL21798198 | 0.67 | MEN1 (0.38) | EGLN1SMN1; SMN2MEN1KMT2AMMP1 | |
| SCHEMBL5254651 | 0.67 | LMNA (0.57) | SMN1; SMN2MEN1KMT2AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044150-A1 | IDENTIFICATION OF COMPOUNDS WHICH INHIBIT ATG8-ATG3 PROTEIN-PROTEIN INTERACTION AND THEIR USE AS ANTIPARASITICAL AGENTS | UNIV JOHNS HOPKINS (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170044150-A1 | IDENTIFICATION OF COMPOUNDS WHICH INHIBIT ATG8-ATG3 PROTEIN-PROTEIN INTERACTION AND THEIR USE AS ANTIPARASITICAL AGENTS | UNIV JOHNS HOPKINS (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015164850-A1 | IDENTIFICATION OF COMPOUNDS WHICH INHIBIT ATG8-ATG3 PROTEIN-PROTEIN INTERACTION AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044150-A1 | IDENTIFICATION OF COMPOUNDS WHICH INHIBIT ATG8-ATG3 PROTEIN-PROTEIN INTERACTION AND THEIR USE AS ANTIPARASITICAL AGENTS | ATG7, ATG13, ATG4A | PTPN1 3064/4885HTR2C 2737/4885EGLN1 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.