Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
| ▸ | ATF4 | P18848 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721436 | 0.86 | DRD2 (0.36) | ALDH1A1TP53MCHR1PIK3CA | |
| SCHEMBL652168 | 0.84 | ATF4 (0.43) | ALDH1A1LMNATP53PI4KBATF4 | |
| SCHEMBL652167 | 0.84 | ATF4 (0.43) | ALDH1A1LMNATP53PI4KBATF4 | |
| SCHEMBL1694133 | 0.81 | HRH4 (0.45) | ALDH1A1LMNATP53PI4KBATF4 | |
| SCHEMBL1694125 | 0.80 | ATF4 (0.40) | LMNATP53PI4KBATF4MCHR1 | |
| SCHEMBL653839 | 0.78 | PI4KB (0.61) | ALDH1A1LMNAPI4KB | |
| SCHEMBL656871 | 0.76 | KIF11 (0.46) | ALDH1A1PI4KBATF4MCHR1 | |
| SCHEMBL656870 | 0.76 | KIF11 (0.46) | ALDH1A1PI4KBATF4MCHR1 | |
| SCHEMBL653994 | 0.71 | DRD2 (0.44) | TP53 | |
| SCHEMBL653993 | 0.71 | DRD2 (0.44) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103130-A2 | NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2010-09-16 | — | — | WO | claimed |
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103130-A2 | NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2010-09-16 | — | — | WO | disclosed |