Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17210879 | 0.89 | GSK3B (0.41) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17210892 | 0.86 | DDX3X (0.48) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17210882 | 0.85 | MAOA (0.47) | MAPTALDH1A1KMT2AGSK3BADK | |
| SCHEMBL17210881 | 0.84 | CCR6 (0.53) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL15797125 | 0.84 | CAMK2D (0.46) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL15797225 | 0.84 | HDAC6 (0.43) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17210884 | 0.84 | GSK3B (0.50) | MAPTALDH1A1MEN1KMT2AGSK3B | |
| SCHEMBL15797024 | 0.83 | GSK3B (0.47) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17210887 | 0.82 | MAPT (0.43) | MAPTALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17236469 | 0.81 | PDE9A (0.40) | MAPTALDH1A1MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993463-B2 | Use of maleimide derivatives for preventing and treating cancer | CENTOGENE AG (DE) | 2018-06-12 | — | — | US | disclosed |
| US-9724331-B2 | Use of maleimide derivatives for preventing and treating leukemia | CENTOGENE AG (DE) | 2017-08-08 | — | — | US | disclosed |
| US-20150313882-A1 | USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER | CENTOGENE AG (DE) | 2015-11-05 | — | — | US | disclosed |
| US-20150306070-A1 | USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING LEUKEMIA | CENTOGENE AG (DE) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313882-A1 | USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER | MGMT, CBR3, IDH3A | MAPT 4752/4885ALDH1A1 346/4885MEN1 167/4885 |
| US-20150306070-A1 | USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING LEUKEMIA | MCL1, NPM1, FLI1 | MAPT 4847/4885ALDH1A1 373/4885MEN1 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.