Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721155 | 1.00 | SIGMAR1 (0.43) | SIGMAR1L3MBTL1POLBDRD2DRD4 | |
| SCHEMBL146403 | 0.87 | KMT2A (0.45) | SIGMAR1L3MBTL1DRD2DRD4DRD3 | |
| SCHEMBL146402 | 0.87 | KMT2A (0.45) | SIGMAR1L3MBTL1DRD2DRD4DRD3 | |
| SCHEMBL459129 | 0.87 | KMT2A (0.45) | SIGMAR1L3MBTL1DRD2DRD4DRD3 | |
| SCHEMBL3919781 | 0.82 | CCR2 (0.44) | SIGMAR1S1PR1S1PR5 | |
| SCHEMBL3919779 | 0.82 | CCR2 (0.44) | SIGMAR1S1PR1S1PR5 | |
| SCHEMBL3928674 | 0.80 | SIGMAR1 (0.44) | SIGMAR1L3MBTL1POLBDRD2DRD4 | |
| SCHEMBL3928676 | 0.80 | SIGMAR1 (0.44) | SIGMAR1L3MBTL1POLBDRD2DRD4 | |
| SCHEMBL3931359 | 0.79 | SIGMAR1 (0.41) | SIGMAR1DRD2DRD4DRD3CHRM4 | |
| SCHEMBL3931356 | 0.79 | SIGMAR1 (0.41) | SIGMAR1DRD2DRD4DRD3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |