Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436717 | 0.84 | HSD17B10 (0.33) | GDAHDAC6KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5349497 | 0.84 | HDAC6 (0.36) | SYKHDAC6KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31269349 | 0.84 | HSD17B10 (0.33) | GDAHDAC6KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6046332 | 0.82 | KDM4E (0.31) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL7771667 | 0.82 | SLC2A1 (0.37) | GDASYKHDAC6KDM4EALDH1A1 | |
| SCHEMBL4520168 | 0.82 | HDAC6 (0.32) | HDAC6KDM4EALDH1A1GLAGAA | |
| SCHEMBL27486869 | 0.79 | ABL1 (0.36) | MAPK1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL6060475 | 0.78 | CTNNB1 (0.30) | — | |
| SCHEMBL23409493 | 0.75 | HTT (0.39) | GDASYKHSD17B10 | |
| SCHEMBL30842861 | 0.75 | HTT (0.39) | GDASYKHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | claimed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | claimed |
| JP-4184279-B2 | — | — | 2008-11-19 | — | — | JP | claimed |
| EP-1255764-B8 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | claimed |
| JP-2005513043-A | — | — | 2005-05-12 | — | — | JP | claimed |
| EP-1456219-A1 | Crystalline form of a ribofuranosyluronamide derivative; a human adenosine A2a receptor agonist | Pfizer Limited (GB) | 2004-09-15 | — | — | EP | claimed |
| JP-2004508284-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1397140-A2 | COMBINATION OF AN ADENOSINE A2A-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-03-17 | — | — | EP | claimed |
| WO-2003047597-A1 | COMBINATION OF CRYSTALLINE FORM OF A RIBOFURANOSYLURONAMIDE DERIVATIVE AND TIOTROPIUM SALT | PFIZER LIMITED (GB) | 2003-06-12 | — | — | WO | claimed |
| WO-2003048180-A1 | CRYSTALLINE FORM OF A RIBOFURANOSYLURONAMIDE DERIVATIVE; A HUMAN ADENOSINE A2A RECEPTOR AGONIST | PFIZER LIMITED (GB) | 2003-06-12 | — | — | WO | claimed |
| WO-2002094273-A2 | COMBINATION OF AN ADENOSINE A2A-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-11-28 | — | — | WO | claimed |
| EP-1255764-A1 | PURINE DERIVATIVES | PFIZER INC. (US) | 2002-11-13 | — | — | EP | claimed |
| EP-1185542-A2 | PURINE DERIVATIVES | Pfizer Limited (GB) | 2002-03-13 | — | — | EP | claimed |
| WO-2001060835-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-08-23 | — | — | WO | claimed |
| WO-2000077018-A2 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-12-21 | — | — | WO | claimed |
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |
| WO-2002022630-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001094368-A1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001060835-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-08-23 | — | — | WO | disclosed |