Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14125935 | 0.84 | KDM4E (0.46) | HPGDMAPK1KMT2AALDH1A1KDM4E | |
| SCHEMBL7771667 | 0.83 | SLC2A1 (0.37) | HPGDKMT2ATDP1ALDH1A1CDK8 | |
| SCHEMBL5349497 | 0.81 | HDAC6 (0.36) | HPGDKMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL31269349 | 0.81 | HSD17B10 (0.33) | HPGDALDH1A1KDM4E | |
| SCHEMBL4436717 | 0.81 | HSD17B10 (0.33) | HPGDALDH1A1KDM4E | |
| SCHEMBL4520168 | 0.79 | HDAC6 (0.32) | HPGDALDH1A1KDM4E | |
| SCHEMBL1721310 | 0.79 | GDA (0.39) | HPGDMAPK1ALDH1A1CDK8KDM4E | |
| SCHEMBL3426594 | 0.76 | MMP12 (0.32) | ABL1HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL30119558 | 0.75 | ALDH1A1 (0.46) | ABL1HPGDNPSR1SRCALDH1A1 | |
| SCHEMBL6060475 | 0.75 | CTNNB1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1179970-C | Purine derivatives | ������ҩ������˾ | 2004-12-15 | — | — | CN | disclosed |
| CN-1374966-A | Purine derivatives | PFIZER LTD (US) | 2002-10-16 | — | — | CN | disclosed |