Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GRK6 | P43250 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18552307 | 0.89 | KDM4E (0.38) | NR4A2KDM4EALDH1A1GRK6RXRA | |
| SCHEMBL17213153 | 0.85 | KDM4E (0.35) | NR4A2KDM4EALDH1A1GRK6RXRA | |
| SCHEMBL18540629 | 0.84 | GRK6 (0.37) | KDM4EALDH1A1GRK6MEN1KMT2A | |
| SCHEMBL21763970 | 0.84 | PRKAG1 (0.36) | GRK6 | |
| SCHEMBL21763923 | 0.82 | CREBBP (0.38) | GRK6 | |
| SCHEMBL21763883 | 0.80 | KDM4E (0.41) | KDM4EGRK6MEN1KMT2A | |
| SCHEMBL21763888 | 0.80 | GRK6 (0.37) | KDM4EALDH1A1GRK6HPGDRECQL | |
| SCHEMBL21763949 | 0.80 | GRK6 (0.35) | GRK6 | |
| SCHEMBL21763919 | 0.79 | HSD11B1 (0.35) | KDM4EALDH1A1GRK6MEN1KMT2A | |
| SCHEMBL21763951 | 0.79 | FAAH (0.39) | GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |