Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.40 |
| ▸ | KDM6B | O15054 | 3/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798742 | 0.88 | KDM4C (0.42) | RAB9AALDH1A1NPC1TP53SMN1; SMN2 | |
| SCHEMBL17439049 | 0.76 | KDM5A (0.48) | ALDH1A1KMT2AMEN1KDM4CKDM6B | |
| SCHEMBL17438513 | 0.75 | KDM5A (0.47) | ALDH1A1KMT2AMEN1KDM4CKDM6B | |
| SCHEMBL4673791 | 0.75 | KDM4E (0.58) | ALDH1A1KMT2AMEN1KDM4CKDM6B | |
| SCHEMBL12516911 | 0.75 | KDM4C (0.53) | ALDH1A1KMT2AMEN1KDM4CKDM6B | |
| SCHEMBL7224946 | 0.74 | KDM5A (0.43) | ALDH1A1KMT2AKDM4CKDM6BKDM5A | |
| SCHEMBL13162018 | 0.73 | SIRT3 (0.56) | SMN1; SMN2KMT2AKDM4CKDM6BKDM5A | |
| SCHEMBL30138224 | 0.73 | SIRT3 (0.56) | SMN1; SMN2KMT2AKDM4CKDM6BKDM5A | |
| SCHEMBL20053816 | 0.72 | KDM4C (0.48) | RAB9AALDH1A1NPC1TP53SMN1; SMN2 | |
| SCHEMBL14917464 | 0.72 | KDM4E (0.46) | ALDH1A1KMT2AMEN1KDM4CKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |