Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15556329 | 0.84 | TDP1 (0.35) | PTPN11MAPK1TDP1 | |
| SCHEMBL16471341 | 0.80 | KMT2A (0.36) | PTPN11 | |
| SCHEMBL21404172 | 0.74 | PYCR1 (0.34) | PTPN11MAPK1 | |
| SCHEMBL22881654 | 0.74 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL30632023 | 0.74 | PYCR1 (0.34) | PTPN11MAPK1 | |
| SCHEMBL15556764 | 0.74 | CYP3A4 (0.44) | PTPN11TDP1 | |
| SCHEMBL16478056 | 0.73 | TRPV4 (0.52) | MAPK1TDP1 | |
| SCHEMBL17831729 | 0.69 | ESRRA (0.40) | PTPN11 | |
| SCHEMBL15557574 | 0.69 | HSD17B10 (0.53) | MAPK1TDP1 | |
| SCHEMBL1921804 | 0.69 | KCNH2 (0.48) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | PTPN11 2138/4885MAPK1 2229/4885TDP1 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.