Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 4/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721093 | 0.82 | FFAR4 (0.67) | FFAR4KMT2AMEN1ALPLNPC1 | |
| SCHEMBL1050952 | 0.80 | MEN1 (0.66) | KMT2AMEN1MAPTALPLSLC40A1 | |
| SCHEMBL1055634 | 0.77 | MEN1 (0.65) | KMT2AMEN1MAPTALPLSLC40A1 | |
| SCHEMBL12167785 | 0.73 | MMP2 (0.67) | KMT2AMEN1MAPTSLC40A1NPC1 | |
| SCHEMBL29139940 | 0.72 | KMT2A (0.64) | KMT2AMEN1NPC1GAAHPGD | |
| SCHEMBL1957070 | 0.72 | KMT2A (0.51) | FFAR4KMT2AMEN1NPC1GAA | |
| SCHEMBL1053050 | 0.71 | MEN1 (0.60) | KMT2AMEN1MAPTALPLSLC40A1 | |
| SCHEMBL4276324 | 0.71 | TAAR1 (0.64) | FFAR4KMT2AMEN1MAPTNPC1 | |
| SCHEMBL2741010 | 0.70 | NPC1 (0.66) | KMT2AMEN1MAPTSLC40A1NPC1 | |
| SCHEMBL4475675 | 0.70 | TSHR (0.59) | FFAR4KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406248-B1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | CBR3, OPRD1, CBR1 | FFAR4 4244/4885KMT2A 2849/4885MEN1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.