Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.67 |
| ▸ | ALPL | P05186 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721571 | 0.82 | FFAR4 (0.64) | FFAR4ALPLMEN1KMT2AALDH1A1 | |
| SCHEMBL4276324 | 0.70 | TAAR1 (0.64) | FFAR4MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL4475675 | 0.69 | TSHR (0.59) | FFAR4KMT2ATDP1LMNA | |
| SCHEMBL4466412 | 0.67 | CYP11B1 (0.56) | FFAR4ALDH1A1TP53GAALMNA | |
| SCHEMBL12412147 | 0.67 | GRM5 (0.61) | ALDH1A1LMNA | |
| SCHEMBL3717535 | 0.66 | ALDH1A1 (0.62) | ALPLMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL4478047 | 0.65 | GRM5 (0.59) | FFAR4KMT2AALDH1A1LMNA | |
| SCHEMBL13606235 | 0.65 | FFAR4 (0.56) | FFAR4ALDH1A1TDP1GAALMNA | |
| SCHEMBL17104293 | 0.65 | FFAR4 (0.52) | FFAR4GAANPC1HPGDRAB9A | |
| SCHEMBL12412646 | 0.65 | GRM5 (0.77) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406248-B1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | CBR3, OPRD1, CBR1 | FFAR4 4244/4885ALPL 3435/4885MEN1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.