Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648359 | 0.85 | POLB (0.37) | FAAHCXCR2SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL4385673 | 0.83 | SMN1; SMN2 (0.51) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL3996623 | 0.82 | FAAH (0.55) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL1721285 | 0.82 | FAAH (0.47) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL4096169 | 0.81 | POLB (0.51) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL6831614 | 0.81 | NPC1 (0.47) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL8932447 | 0.77 | POLB (0.44) | RAB9APOLBMEN1KMT2A | |
| SCHEMBL1721706 | 0.77 | POLB (0.44) | RAB9APOLBMEN1KMT2A | |
| SCHEMBL2320404 | 0.77 | FAAH (0.59) | FAAHSMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL6190128 | 0.77 | FAAH (0.48) | FAAHSMN1; SMN2MAPK1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406247-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |
| EP-1701933-B1 | NOVEL COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-09-03 | — | — | EP | disclosed |
| EP-1701933-A1 | NOVEL COMPOUNDS | TANABE SEIYAKU CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005061440-A1 | NOVEL COMPOUNDS | TANABE SEIYAKU CO., LTD. (JP) | 2005-07-07 | — | — | WO | disclosed |