Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721602 | 0.90 | PTPN1 (0.47) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL1721886 | 0.90 | PTPN1 (0.47) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL421440 | 0.86 | HSD11B1 (0.49) | HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL418949 | 0.86 | HSD11B1 (0.59) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL421285 | 0.84 | HSD11B1 (0.47) | HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL419871 | 0.84 | HSD11B1 (0.51) | HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL420589 | 0.77 | HSD11B1 (0.46) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL418097 | 0.76 | HSD11B1 (0.60) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL418948 | 0.76 | HSD11B1 (0.57) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL1720988 | 0.74 | HSD11B1 (0.77) | PTPN1HSD11B1HSD11B2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406272-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | onepharm Research & Development GmbH (AT) | 2012-01-18 | — | — | EP | disclosed |