Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.31 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721602 | 0.92 | PTPN1 (0.47) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL1721806 | 0.90 | PTPN1 (0.44) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL418948 | 0.85 | HSD11B1 (0.57) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL420589 | 0.85 | HSD11B1 (0.46) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL421484 | 0.83 | HSD11B1 (0.48) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL418097 | 0.82 | HSD11B1 (0.60) | PTPN1HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL421440 | 0.76 | HSD11B1 (0.49) | HSD11B1HSD11B2CES2CES1 | |
| SCHEMBL418949 | 0.76 | HSD11B1 (0.59) | PTPN1HSD11B1HSD11B2CYP3A4TSHR | |
| SCHEMBL1721809 | 0.75 | PTPN1 (0.67) | PTPN1PTPN2EGLN2EGLN1EGLN3 | |
| SCHEMBL421285 | 0.73 | HSD11B1 (0.47) | HSD11B1HSD11B2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406272-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | onepharm Research & Development GmbH (AT) | 2012-01-18 | — | — | EP | disclosed |