Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722156 | 1.00 | GAA (0.44) | GAATP53CHRNB2CHRNA4POLB | |
| SCHEMBL13804385 | 0.90 | CHRNB2 (0.47) | GAATP53CHRNB2CHRNA4POLB | |
| SCHEMBL13804289 | 0.90 | CHRNB2 (0.47) | GAATP53CHRNB2CHRNA4POLB | |
| SCHEMBL13804282 | 0.90 | CHRNB2 (0.47) | GAATP53CHRNB2CHRNA4POLB | |
| SCHEMBL13804258 | 0.90 | CHRNB2 (0.47) | GAATP53CHRNB2CHRNA4POLB | |
| SCHEMBL19893800 | 0.85 | MAPT (0.47) | GAAALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL4222468 | 0.85 | MAPT (0.47) | GAAALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL19909758 | 0.85 | MAPT (0.47) | GAAALDH1A1PPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL19893791 | 0.83 | MAPT (0.46) | GAAALDH1A1PPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL19893793 | 0.83 | MAPT (0.46) | GAAALDH1A1PPM1BPTPN1PPP1CC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084445-B2 | Broad-spectrum carbapenems | VenatoRx Pharmaceuticals, Inc. (US) | 2024-09-10 | — | — | US | disclosed |
| US-20210188851-A1 | BROAD-SPECTRUM CARBAPENEMS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-06-24 | — | — | US | disclosed |
| US-8759365-B2 | Organic compounds | NOVARTIS AG (CH) | 2014-06-24 | — | — | US | disclosed |
| EP-2404901-A1 | 1,2-Disubstituted 4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis | Novartis AG (CH) | 2012-01-11 | — | — | EP | disclosed |
| EP-2229356-B1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| US-20100311750-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311750-A1 | ORGANIC COMPOUNDS | CETP, NPC1, CES1 | GAA 641/4885TP53 1022/4885CHRNB2 3814/4885 |
| US-20210188851-A1 | BROAD-SPECTRUM CARBAPENEMS | MGAM, ALPI, SI | GAA 19/4885TP53 4728/4885CHRNB2 4825/4885 |
| US-12084445-B2 | Broad-spectrum carbapenems | MGAM, ALPI, SI | GAA 19/4885TP53 4728/4885CHRNB2 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.