Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721513 | 0.77 | KMT2A (0.42) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8109351 | 0.76 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1722601 | 0.75 | KDM4E (0.41) | PDE7AELANEKDM4ERXFP1TDP1 | |
| SCHEMBL3110055 | 0.71 | PDE10A (0.56) | ELANEKDM4ERXFP1TDP1ALDH1A1 | |
| SCHEMBL8109356 | 0.67 | GRM5 (0.43) | KDM4ERXFP1TDP1MAPTNPC1 | |
| SCHEMBL12204686 | 0.66 | KMT2A (0.53) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL20885167 | 0.62 | KMT2A (0.57) | KDM4ERXFP1ALDH1A1RAB9AMEN1 | |
| SCHEMBL9601532 | 0.61 | MAPT (0.41) | PDE7AELANEKDM4EALDH1A1MAPT | |
| SCHEMBL8986839 | 0.61 | PDE7A (0.68) | PDE7AKDM4ETDP1ALDH1A1NPC1 | |
| SCHEMBL15195139 | 0.61 | PDE7A (0.68) | PDE7AKDM4ETDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406228-B1 | Substituted 3-amino-2-mercaptochinolins as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-09-18 | — | — | EP | disclosed |
| US-8207342-B2 | Substituted 3-amino-2-mercaptoquinolines as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| EP-2406228-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102779-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | disclosed |
| US-20100234421-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234421-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNQ3 | PDE7A 2879/4885ELANE 4806/4885KDM4E 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.