Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109351 | 0.76 | ALDH1A1 (0.47) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL6785535 | 0.72 | NPC1 (0.53) | LMNAMAPK1SMN1; SMN2RXFP1MAOB | |
| SCHEMBL6635377 | 0.72 | PDCD1 (0.42) | GRM5PKMMAPK1SMN1; SMN2RXFP1 | |
| SCHEMBL6638692 | 0.71 | GRM5 (0.48) | GRM5MAOBPDCD1CD274MEN1 | |
| SCHEMBL1721513 | 0.69 | KMT2A (0.42) | LMNAMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1722353 | 0.67 | PDE7A (0.43) | MAPK1SMN1; SMN2RXFP1MEN1KMT2A | |
| SCHEMBL30010206 | 0.66 | PDCD1 (0.70) | GRM5PDCD1CD274 | |
| SCHEMBL28590561 | 0.66 | PDCD1 (0.70) | GRM5PDCD1CD274 | |
| SCHEMBL13107075 | 0.65 | SMN1; SMN2 (0.42) | PKMMAPK1SMN1; SMN2RXFP1MAOB | |
| SCHEMBL13096745 | 0.64 | MAOB (0.48) | LMNAPKMMAPK1SMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |