Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 16/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR1E | P28566 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31091535 | 0.78 | MAOB (0.50) | MAOAMAOBDRD1TRPA1CNR1 | |
| SCHEMBL15349084 | 0.78 | MAOB (0.50) | MAOAMAOBDRD1TRPA1CNR1 | |
| SCHEMBL15688472 | 0.76 | DRD1 (0.49) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL15688482 | 0.76 | DRD1 (0.55) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL15688267 | 0.76 | DRD1 (0.63) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL23969546 | 0.75 | DRD1 (0.48) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL15688312 | 0.75 | DRD1 (0.48) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL21999457 | 0.75 | DRD1 (0.58) | DRD1TRPA1 | |
| SCHEMBL15688322 | 0.74 | DRD1 (0.59) | DRD1TRPA1ADRB2CHRM2ADRB1 | |
| SCHEMBL615020 | 0.73 | MAOB (0.59) | MAOAMAOBSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137469-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2019-10-09 | — | — | EP | disclosed |
| US-9745317-B2 | Heterocyclic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-08-29 | — | — | US | disclosed |
| EP-3137469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc. (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015166366-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | MAOA 34/4885MAOB 43/4885DRD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.